Diabetes / GSH research

Diabetes / GSH research

This wk I am going to focus on Diabetes / GSH Just LOOK at this research from 2011!!!!!!!!

CONCLUSIONS Patients with uncontrolled type 2 diabetes have severely deficient synthesis of glutathione attributed to limited precursor availability. Dietary supplementation with GSH precursor amino acids can restore GSH synthesis and lower oxidative stress and oxidant damage in the face of persistent hyperglycemia.

HELLO!!!!! GSH-Immunity is the most efficient least expensive GSH precursor on the market. Please contact me for more info, I LOVE my job!!!!

GSH / Pancreas / oxidative stress

GSH / Pancreas / oxidative stress

Research from 2014: Pancreas / GSH
Our results indicate a deficit in the level of glutathione in the pancreas leads to imbalance in oxidant/antioxidant reactions.
Science knows that GSH is what our cells have to remove excess oxidative damage, you require adequate GSH to do so, if you have an illness you are deficit, allowing our cells to replenish their own GSH is crucial for cell health — organ health — system function = total body health. Please contact me for more info. Have a great wkend

When a person suffers from pancreatitis there is massive oxidative stress and inflammation.

It is crucial in this health crisis that the cells have adequate GSH, GSH removes excess inflammation and as well as Oxidative damage, also in the situation of an infection GSH is in the front line to rid the infection.

GSH is crucial in our cells to maintain optimum function, if cells are healthy, organs are healthy, if organs are healthy then Systems are functioning to their optimum.

GSH rocks!!! I love my job please contact me for more information. Have a great day

Pancreas / GSH

Pancreas / GSH

Going to do a review of Pancreas and GSH this wk!!

I think this is significant:

The pancreas plays a major role, along with the kidney, liver, small intestine, and several other organs, in glutathione (GSH) metabolism, as evidenced by the large concentration of GSH in the pancreas, its rapid turnover rate, and the presence, at significant levels, of various enzymes involved in GSH metabolism

To further this though:

Decreased cellular GSH content is a common finding in experimental and human diabetes, in which increased oxidative

stress appears to occur. Oxidative stress has been suggested to

play a causative role in the development of impaired insulin

action on adipose tissue and skeletal muscle.

So if you wish to have adequate GSH and a healthy Pancreas you need to allow your cells to replenish GSH daily, please contact me for more information, have a great day

GSH / Oxidative stress

GSH / Oxidative stress

Research 2008:

Regardless of the mechanisms, antioxidants decrease oxidative stress and restore redox balance in biologic systems.

GSH is the Master Antioxidant, in order to do this particular job you require adequate GSH, please contact me for more info in order to attain and maintain health.

Have a great wkend take care

GSH / Lung inflammation research

GSH / Lung inflammation research

Awesome research showing importance of GSH in the lungs:
Eur Respir J. 2000 Sep;16(3):534-54.

Oxidative stress and regulation of glutathione in lung inflammation.

Rahman I1, MacNee W.

Author information

Abstract

Inflammatory lung diseases are characterized by chronic inflammation and oxidant/antioxidant imbalance, a major cause of cell damage. The development of an oxidant/antioxidant imbalance in lung inflammation may activate redox-sensitive transcription factors such as nuclear factor-KB, and activator protein-1 (AP-1), which regulate the genes for pro-inflammatory mediators and protective antioxidant genes. Glutathione (GSH), a ubiquitous tripeptide thiol, is a vital intra- and extracellular protective antioxidant against oxidative/nitrosative stresses, which plays a key role in the control of pro-inflammatory processes in the lungs. Recent findings have suggested that GSH is important in immune modulation, remodelling of the extracellular matrix, apoptosis and mitochondrial respiration. The rate-limiting enzyme in GSH synthesis is gamma-glutamylcysteine synthetase (gamma-GCS). The human gamma-GCS heavy and light subunits are regulated by AP-1 and antioxidant response elements and are modulated by oxidants, phenolic antioxidants, growth factors, and inflammatory and anti-inflammatory agents in lung cells. Alterations in alveolar and lung GSH metabolism are widely recognized as a central feature of many inflammatory lung diseases such as idiopathic pulmonary fibrosis, acute respiratory distress syndrome, cystic fibrosis and asthma. The imbalance and/or genetic variation in antioxidant gamma-GCS and pro-inflammatory versus antioxidant genes in response to oxidative stress and inflammation in some individuals may render them more susceptible to lung inflammation. Knowledge of the mechanisms of GSH regulation and balance between the release and expression of pro- and anti-inflammatory mediators could lead to the development of novel therapies based on the pharmacological manipulation of the production as well as gene transfer of this important antioxidant in lung inflammation and injury. This review describes the redox control and involvement of nuclear factor-kappaB and activator protein-1 in the regulation of cellular glutathione and gamma-glutamylcysteine synthetase under conditions of oxidative stress and inflammation, the role of glutathione in oxidant-mediated susceptibility/tolerance, gamma-glutamylcysteine synthetase genetic susceptibility and the potential therapeutic role of glutathione and its precursors in protecting against lung oxidant stress, inflammation and injury.

Please contact me for more info, have a most wonderful day take care

Pnemonia / Lung fibrosis / GSH research

Pnemonia / Lung fibrosis / GSH research

Lung fibrosis / pneumonia / GSH research 2011

The impact of ROS may be especially important in the lung because of its large surface area and its exposure to higher oxygen levels than other tissues. The lung counters this with a formable array of antioxidant defense systems, starting with high levels of antioxidants in the epithelial lining fluid (ELF). Glutathione (GSH) is a major water-soluble antioxidant thiol in the lung ELF, and its levels are lower in subjects with pnemonia. In addition to GSH, the lung ELF contains other antioxidants such as ascorbate, urate, albumin, mucins, and metal-binding proteins, which are all effective at limiting oxidative damage. The lung also has a number of antioxidant enzyme systems including SODs, catalase, glutathione peroxidases (GPxs), thioredoxin, glutaredoxin, and peroxiredoxins . Overexpression of many of these antioxidant enzyme systems is protective against lung fibrosis. It is likely that inadequate antioxidant adaptive responses plays a key role in lung fibrosis.

Allowing our cells to replenish daily GSH enables the Strong / Balanced Immune system, enables the lungs to rid excess oxidative damage. GSH is crucial for lung cell function.

Please contact me for more info have a great day