Lung fibrosis / pneumonia / GSH research 2011
The impact of ROS may be especially important in the lung because of its large surface area and its exposure to higher oxygen levels than other tissues. The lung counters this with a formable array of antioxidant defense systems, starting with high levels of antioxidants in the epithelial lining fluid (ELF). Glutathione (GSH) is a major water-soluble antioxidant thiol in the lung ELF, and its levels are lower in subjects with pnemonia. In addition to GSH, the lung ELF contains other antioxidants such as ascorbate, urate, albumin, mucins, and metal-binding proteins, which are all effective at limiting oxidative damage. The lung also has a number of antioxidant enzyme systems including SODs, catalase, glutathione peroxidases (GPxs), thioredoxin, glutaredoxin, and peroxiredoxins . Overexpression of many of these antioxidant enzyme systems is protective against lung fibrosis. It is likely that inadequate antioxidant adaptive responses plays a key role in lung fibrosis.
Allowing our cells to replenish daily GSH enables the Strong / Balanced Immune system, enables the lungs to rid excess oxidative damage. GSH is crucial for lung cell function.
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