Epilepsy / GSH / Brain inflammation research 2014
Dysregulation of GSH homeostasis and alterations in GSH-dependent enzyme activities are increasingly implicated in the induction and progression of neuronal diseases, such as epilepsy. It has been widely reported that alterations in the antioxidant system and increases in oxidants are associated with this condition. Epilepsy is one of the most common and serious brain disorders, and it affects at least 50 million people worldwide; in addition, approximately 100 million people will have at least one epileptic seizure during their lifetime.
The brain is particularly susceptible to oxidative stress because it is the organ that utilizes the greatest amount of oxygen within the body. The brain is highly susceptible to damage from excessive oxidative stress. Oxidative stress is regarded as a possible mechanism in the pathogenesis of epilepsy. Furthermore, persistent seizures have been demonstrated to cause cell damage through increases in oxidative stress. Important alterations in the antioxidant system have been found in seizing animals and epileptic patients.
If the body is allowed to replenish its own GSH daily the oxidative stress in the brain is lessened and inflammation can be more easily removed. GSH replenishing aids the epileptic brain. please contact me for more information